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Vaccine distribution plan covid. Rabies is a fatal disease caused by the rabies virus rabv and other lyssaviruses and responsible for an estimated 59000 human deaths every year up to 99 of human cases worldwide are caused by dog bites although there is no cure for clinical rabies the disease is readily preventable through timely provision of adequate post exposure prophylaxis pep. Intradermal rabies vaccination idrv for post exposure prophylaxis was approved by who as early as in 1992 and has now been extensively used in india since 2006. Postexposure prophylaxis pep consists of a dose of human rabies immune globulin hrig and rabies vaccine given on the day of the rabies exposure and then a dose of vaccine given again on days 3 7 and 14.
In a resource limited setting like india high cost of vaccine is a major limiting factor. The third dose is given on the 7 th day from the first dose. Human diploid cell vaccine hdcv purified chick embryo cell vaccine pcecv and purified verocell rabies vaccine pvrv.
First rabies vaccine dose to be given immediately after being bitten or getting in contact with the saliva of an infected animal. Intramuscular regimens for rabies post exposure prophylaxis there are 3 intramuscular schedules for category ii and iii exposures. For people who have never been vaccinated against rabies previously postexposure prophylaxis pep should always include administration of both hrig and rabies vaccine.
The 5 dose regimen the 2 1 1 regimen the 4 dose regimen with rig in both categories ii and iii vaccines should be injected into the deltoid muscle for adults and children aged 2 years and more. Rabies post exposure prophylaxis healthy immunocompetent persons including pregnant women pdf. The second dose is given on the third day.
The vaccines used for pre exposure and post exposure vaccination are the same but the immunization schedule differs. The rabies vaccines available are as follows. A 10 ml dose of rabies vaccine is given im in the deltoid area of adults or the anterolateral thigh of young children on days 0 3 7 and 14 of the rabies pep regimen table 3.
Modern vaccines of cell culture or embryonated egg origin are safer and more effective than the older vaccines which were produced in brain tissue. The post exposure anti rabies vaccine schedule is as follows. Rabies is a viral infection caused by viruses belonging to the lyssavirus genus.
The disease is preventable with rapid administration of post exposure prophylaxis pep after exposure however many of those persons affected by rabies are faced with vaccine shortages or cost. The first vaccination is given concurrently with the hrig at a site. The vaccines approved by the national health authorities shall be used for the intradermal route.
Idrv is found to be equally effective as intramuscular rabies vaccination and at the. It is a zoonosis an animal disease that can spread to humans transmitted by saliva through bites and scratches of infected mammals.
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