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Pfizer stock marketbeat. A live attenuated vaccine based on the sa 14 14 2 strain of the je virus is widely used in china and in an increasing number of countries within the asian region including india the republic of korea sri lanka and thailand. Japanese encephalitis je virus is a single stranded rna virus that belongs to the genus flavivirus and is closely related to west nile and saint louis encephalitis viruses. 18 september 2014 nra of record.
Encephalitis is an infection of the membrane around the brain and spinal cord. Adverse reactions manifesting as generalized urticaria or angioedema may occur within minutes following vaccination. Lyophilised active component to be reconstituted with excipient diluent before use.
Ixiaro vaccine is used to help prevent japanese encephalitis in adults and adolescents who are at least 17 years old. This vaccine was approved in march 2009 for use in people aged 17 years and older and in may 2013 for use in children 2 months through 16 years of age. The vaccine constituents responsible for these events have not been identified 16there has been a detailed report of the adverse effects mainly allergic mucocutaneous reactions of biken vaccine in danish travellers and us.
The inactivated mouse brain derived imb vaccine is now commonly replaced by cell culture based vaccines. Table 14 inactivated japanese encephalitis vaccine produced in primary hamster kidney cells efficacy of 2 doses and booster guangdong province peoples republic of china study number of. Transmission je virus is transmitted to humans through the bite of an infected mosquito primarily culex species.
Contra indications adverse effects precautions do not administer to patients with history of an allergic reaction to a previous injection of japanese encephalitis vaccine. Two types of japanese encephalitis vaccines are provided in travel health centres subject to supply availability inactivated vaccine this vaccine is registered for use in travellers aged 2 months and above. Japanese encephalitis je vaccine is contraindicated in patients who have had angioedema or urticaria after a previous dose of this vaccine or who are allergic to mouse protein neural protein or thimerosal.
Japanese encephalitis vaccine live attenuated manufacturer. Inactivated vero cell culture derived japanese encephalitis je vaccine manufactured as ixiaro is the only je vaccine licensed and available in the united states. The 3 rd dose should be given at least 10 days before departure to ensure an adequate immune response and access to medical care in the event of adverse reactions.
Thai food and drug administration product description. Imojev md vaccine type. It is the leading cause of viral encephalitis inflammation of the brain in asia.
Gpo mbp co ltd country of manufacture. Dosage and route of transmission vaccine is administered subcutaneously in two 05 ml doses one week apart to children six to 12 months of age.
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