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General considerations in rabies post exposure prophylaxis pep who strongly recommends discontinuation of the nerve tissue vaccine and replacement with modern concentrated and purified cell culture derived vaccines ccdv and embryonated egg based rabies vaccines these vaccines must comply with who criteria for potency.
Vaccine watch. Use of a reduced 4 dose vaccine schedule for postexposure prophylaxis to prevent human rabies summary. Rabies post exposure prophylaxis healthy immunocompetent persons including pregnant women pdf. Rabies pre and post exposure treatment in humans current who guide for.
The dose is either 1 standard intra muscular dose. Hrig and the first vaccination are given on the first day of treatment. Vaccination against rabies human diploid cell vaccine hdcv rabivac tm purified vero cell vaccine pvrv.
The rabies pep regimen involves administration of human rabies immune globulin hrig which is given only once and a series of four 10 ml rabies vaccinations table 3. This report summarizes new recommendation and updates previous recommendations of the advisory committee on immunization practices acip for postexposure prophylaxis pep to prevent human rabies cdc.
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