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Pfizer covid interim analysis. We need to continually adapt production process to satisfy evolving regulatory demand which varies country by country. Vaccine production has several stages. Boriana marintcheva in harnessing the power of viruses 2018.
First the antigen itself is generated. Vaccine production in plants is already a fact due to advances of. Vaccines are basically meant to train and strengthen the immune system to develop resistance against anti bodies and illnesses by imitating an infection to create a natural immune response.
There are entire chicken farms in the us and around the world dedicated to producing eggs for the purpose of incubating influenza viruses for use in vaccines. This production method requires large numbers of chicken eggs to produce vaccine and may take longer than other production methods. The vaccine manufacturing facility represents a significant fixed and ongoing maintenance cost for the vaccine manufacturer.
A very attractive idea for alternative vaccine production and delivery is genetically engineering plants to produce vaccines that would be delivered to the human body as part of our diet ie by eating traditional fruits and vegetables. Manufacturing vaccine is a biological process where a very high level of expertise is required. Most of the active types of vaccines remain in the system as anti bodies even after they have completed their process of creating a stronger immunity system.
The production of a vaccine can take between 6 and 36 months vaccines manufacturing is a biological process where a very high level of expertise is required. Successful manufacturing of high quality vaccines requires international standardization of starting materials production and quality control testing and the setting of high expectations for regulatory oversight of the entire manufacturing process from start to finish all while recognizing that this field is in constant change 1. Viruses are grown either on primary cells such as chicken eggs eg for influenza or on continuous cell lines.
This requires careful assessment of market opportunity to determine optimal capacity. Vaccine for hepatitis b is successfully made in banana. Vaccine for cholera is successfully developed in potato banana is the ideal plant for oral vaccine production due to its excellent digestibility palatability and availability throughout the year.
We need to continually adapt production process to satisfy evolving regulatory demand which varies country by country.
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