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The rvsv zebov vaccine is a single dose vaccine regimen that has been found to be safe and protective against only the zaire ebolavirus species of ebolavirus.
Vaccine distribution plan us. 6 the surface glycoprotein mediates viral entry into host cells 78 and has. During the early 21st century several vaccine candidates displayed efficacy to protect nonhuman primates usually macaques against. Ebola virus disease evd is caused by one of five species of ebola viruses namely zaire sudan tai forest bundibugyo and reston with the most fatal specie being the zaire virus ref.
Ebola virus disease vaccines. The sabin vaccine institute has also licensed the cad3 platform to develop vaccines against sudan virus another ebola virus species and marburg virus. Around half the people given the vaccine have mild to moderate adverse effects that include.
An investigational vaccine called rvsv zebov which has shown to be safe and protective against the zaire strain of the ebola virus is recommended by the strategic advisory group of experts on immunization sage 1 for use in ebola outbreaks caused by the zaire strain of the virus in the event where there is no licensed vaccine. When used in ring vaccination rvsv ebov has shown a high level of protection. This is the first fda approval of a vaccine.
Food and drug administration fda approved the ebola vaccine rvsv zebov tradename ervebo on december 19 2019. Ebola virus is a filovirus with a 19 kb nonsegmented negative strand rna genome that encodes seven viral proteins. If these vaccines work for ebola zaire it is very likely that the same principles can be applied to the other strains.
Ebola zaire is the strain of the virus that is responsible for the 2014 outbreak. Niaid and wrair are conducting a clinical trial examining the safety and dosage of an investigational vaccine designed to protect against sudan virus known as cad3 ebo s at makerere. It had been used extensively in the kivu ebola epidemic under a compassionate use protocol.
Recombinant vesicular stomatitis viruszaire ebola virus rvsv zebov also known as ebola zaire vaccine live and sold under the brand name ervebo is a vaccine for adults that prevents ebola caused by the zaire ebolavirus. Over the years there have been several outbreaks in zaire democratic republic of congo uganda sudan gabon and congo. Accordingly all of the vaccine candidates being advanced are designed to prevent that strain.
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