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The vaccine works meme. Unlike dengue virus ade in sars and mers is not triggered by a heterovirus strain however it is clear that the effects of both have negative consequences for the human body and are probably an obstacle to the development of viral vaccines yong et al 2019. Such concerns are real. One possible answer is antibody dependent enhancement ade of sars cov 2 due to prior exposure to other coronaviruses.
This is a decisive issue during late clinical stages of vaccine development against covid 19. Risk of ade low with new chinese vaccine candidate researchers say antibody dependent enhancement ade is a side effect of inoculation that can make a virus more harmful. Might covid 19 vaccines sensitize humans to antibody dependent enhanced ade breakthrough infections.
To add to the concern antibodies typical of ade are present in the blood of some covid 19 patients. Antibody dependent enhancement can hamper vaccine development as a vaccine may cause the production of antibodies which via ade worsen the disease the vaccine is designed to protect against. Burton says vaccine tests in animal models will help researchers understand the likelihood of ade occurring in a covid 19 vaccine although that wont be conclusive proof until clinical tests in humans are conducted.
Might covid 19 vaccines sensitize humans to antibody dependent enhanced ade breakthrough infections. Furthermore the vaccine is not indicated for children under the age of 9 years. Encouragingly some recent preliminary vaccine studies found no evidence of ade.
The considerable investment and fierce competition in developing a covid 19 vaccine means there is a higher chance than. Ade has been observed in previous attempts to develop coronavirus vaccines. Whether ade works in other kinds of coronavirus infections remains to be investigated.
This is unlikely because coronavirus diseases in humans lack the clinical epidemiological biological or pathological attributes of ade disease exemplified by dengue viruses denv.
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