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Shortening Intradermal Rabies Post Exposure Prophylaxis Regimens To 1 Week Results From A Phase Iii Clinical Trial In Children Adolescents And Adults Vaccine Phase Trials Duration
Vaccine phase trials duration. The first dose of the 4 dose course should be administered as soon as possible after exposure day 0. Intramuscular regimens for rabies post exposure prophylaxis. A 10 ml dose of rabies vaccine is given im in the deltoid area of adults or the anterolateral thigh of young children on days 0 3 7 and 14 of the rabies pep regimen table 3.
Postexposure prophylaxis pep consists of a dose of human rabies immune globulin hrig and rabies vaccine given on the day of the rabies exposure and then a dose of vaccine given again on days 3 7 and 14. 5 i u m l titre 05 iuml rabies post exposure prophylaxis pep dose schedule rig rabies immune globulin volume based. Previously unvaccinated persons should receive 5 intramuscular doses 1 ml each of imovax rabies vaccine one dose immediately after exposure day 0 and one dose 3 7 14 and 28 days later.
Rig rabies immune globulin rig 20 iukg on day 0 in conjunction with the first vaccine dose. For persons previously unvaccinated with rabies vaccine the reduced regimen of 4 1 ml doses of hdcv or pcecv should be administered intramuscularly. The first vaccination is given concurrently with the hrig at a site.
Usual adult dose for rabies prophylaxis. 5 doses vaccine day 03714 and 28 rabies immune globulin rig based on body weight day 0 4 doses vaccine day 03714 discontinue immunization after day 3 dose of vaccine day 714 not necessary t i t r e 0. Additional doses then should be administered on days 3 7 and 14 after the first vaccination.
For persons previously unvaccinated with rabies vaccine the reduced regimen of 4 1 ml doses of hdcv or pcecv should be administered intramuscularly. The first dose of the 4 dose course should be administered as soon as possible after exposure day 0. 1 1 1 1 1 one dose of the vaccine should be administered on days 0 3 7 14 and 28 given in the deltoid region or for young children into the antero lateral area of the thigh muscle.
3 doses 1 ml each im on days 0 7 and 21 or 28. Recommendations of the advisory committee on immunization practices mmwr recomm rep 2010. 1 dose 1 ml im.
Rabies immunoglobulin should not be administered. The 5 dose intramuscular regime. Rabies post exposure prophylaxis healthy immunocompetent persons including pregnant women pdf.
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